Supernatural star Misha Collins responded positively to the cancellation of The Winchesters, despite the efforts of executive producer Jensen Ackles to find a new home for the show. While the #SaveTheWinchesters campaign was unsuccessful, Collins acknowledged the hard work of the team behind the show and remained hopeful that it was just an obstacle that could be overcome.
The CW's new owners, Nexstar, have shifted away from scripted original programming, resulting in many show cancellations. Efforts to save The Winchesters included interest from various streaming platforms, though the ongoing WGA strike for fair wages contributed to the lack of interest. Nevertheless, hopes remain high for a revival of the franchise in the future.