Jennifer Aniston, who came from a family of actors and had industry connections, struggled to make it in Hollywood before finding her big break as Rachel Green on the hit sitcom Friends. Prior to Friends, she had unsuccessful stints on the TV shows Molloy and Ferris Bueller.

Despite those failures, Aniston continued to pursue other opportunities and eventually auditioned for Friends, turning down a spot on Saturday Night Live. Her caution paid off when Friends became wildly successful, surpassing expectations and launching her acting career.