The Winchesters' latest episode features a big villain reveal that may prove a popular theory connecting the spinoff to Supernatural. The introduction of parallel universes in later seasons of Supernatural, with alternate dimensions created by God, paved the way for a multiverse concept. The Winchesters' season 1, episode 7, confirms suspicions that its main villains, the Akrida, originate from a parallel universe, suggesting that The Winchesters and Supernatural take place in completely different universes. This also sets the stage for a potential crossover between the two shows.